Imaging, Diagnosis, Prognosis Development of [C]erlotinib Positron Emission Tomography for In Vivo Evaluation of EGF Receptor Mutational Status
نویسندگان
چکیده
Purpose: To evaluate whether, in patients with non–small cell lung carcinoma (NSCLC), tumor uptake of [C]erlotinib can be quantified and imaged using positron emission tomography and to assess whether the level of tracer uptake corresponds with the presence of activating tumor EGF receptor
منابع مشابه
Development of [C]erlotinib Positron Emission Tomography for In Vivo Evaluation of EGF Receptor Mutational Status
Purpose: To evaluate whether, in patients with non–small cell lung carcinoma (NSCLC), tumor uptake of [C]erlotinib can be quantified and imaged using positron emission tomography and to assess whether the level of tracer uptake corresponds with the presence of activating tumor EGF receptor
متن کاملDevelopment of [(11)C]erlotinib positron emission tomography for in vivo evaluation of EGF receptor mutational status.
PURPOSE To evaluate whether, in patients with non-small cell lung carcinoma (NSCLC), tumor uptake of [(11)C]erlotinib can be quantified and imaged using positron emission tomography and to assess whether the level of tracer uptake corresponds with the presence of activating tumor EGF receptor (EGFR) mutations. EXPERIMENTAL DESIGN Ten patients with NSCLCs, five with an EGFR exon 19 deletion, a...
متن کاملDetection of Alzheimer\\\\\\\'s Disease using Multitracer Positron Emission Tomography Imaging
Alzheimer's disease is characterized by impaired glucose metabolism and demonstration of amyloid plaques. Individual positron emission tomography tracers may reveal specific signs of pathology that is not readily apparent on inspection of another one. Combination of multitracer positron emission tomography imaging yields promising results. In this paper, 57 Alzheimer's disease neuroimaging ini...
متن کاملNeuroimaging in Iran: A Review
ABSTRACTNeuroimaging allows noninvasive evaluation of the anatomy, physiology, and function of the brain. It is widely used for diagnosis, treatment planning, and treatment evaluation of neurological disorders as well as understanding functions of the brain in health and disease. Neuroimaging modalities include X-ray computed tomography (CT), magnetic resonance imaging (MRI), single photon emis...
متن کاملIdentifying erlotinib-sensitive non-small cell lung carcinoma tumors in mice using [11C]erlotinib PET
BACKGROUND Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine kinase (TK) domain of the EGFR are detected in 10% to 30% of NSCLC patients, and evidence of their presence is a prerequisite for initiation of first-line therapy with selective ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012